Investors can expect a company’s stock to rise or fall based on the buying and selling of stock by its insiders. Ionis Pharmaceuticals Inc shares valued at $1,100,385 were sold by WENDER JOSEPH H on Oct 01 ’25. At $65.50 per share, WENDER JOSEPH H sold 16,800 shares. The insider’s holdings dropped to 92,035 shares worth approximately $6.3 million following the completion of this transaction.
Also, Swayze Eric sold 14,142 shares, netting a total of over 934,662 in proceeds. Following the sale of shares at $66.09 each, the insider now holds 37,302 shares.
Before that, Swayze Eric had sold 12,972 shares from its account. In a trade valued at $859,082, the EVP Research traded Ionis Pharmaceuticals Inc shares for $66.23 each. Upon closing the transaction, the insider’s holdings decreased to 12,972 shares, worth approximately $2.55 million.
As published in a research note from Goldman on September 26, 2025, Ionis Pharmaceuticals Inc [IONS] has been rated up from a Sell to a Neutral and the price target has been revised to $65. Analysts at BMO Capital Markets upgraded the stock from ‘”a Market perform”‘ to ‘”an Outperform”‘ outlook in a report released in early September. As of July 31, 2025, Morgan Stanley has increased its “an Equal-weight” rating to a “an Overweight” for IONS. Earlier on July 01, 2025, Barclays upgraded its rating. Their new recommendation was “an Overweight” for IONS stock which previously was a “an Equal weight”.
Analyzing IONS Stock Performance
On last trading session, Ionis Pharmaceuticals Inc [NASDAQ: IONS] rose 3.95% to $68.4. The stock’s lowest price that day was $65.97, but it reached a high of $68.41 in the same session. During the last five days, there has been a surge of approximately 8.62%. Over the course of the year, Ionis Pharmaceuticals Inc shares have jumped approximately 70.74%. Shares of the company reached a 52-week high of $68.41 on 10/02/25 and a 52-week low of $23.95 on 04/09/25.
Support And Resistance Levels for Ionis Pharmaceuticals Inc (IONS)
According to the 24-hour chart, there is a support level at 66.78, which, if violated, would cause prices to drop to 65.15. In the upper region, resistance lies at 69.22. The next price resistance is at 70.03. RSI (Relative Strength Index) is 79.37 on the 14-day chart, showing overbought technical sentiment.
Is Ionis Pharmaceuticals Inc subject to short interest?
Stocks of Ionis Pharmaceuticals Inc saw a sharp rise in short interest on 2025-09-15 jumping by 1.19 million shares to 11.97 million. Data from Yahoo Finance shows that the short interest on 2025-08-15 was 10.79 million shares. A jump of 9.92% in short interest reflects a negative sentiment towards the stock. Despite the fact that short shares comprise just 3.69 of the overall float, the days-to-cover ratio (short ratio) jumped to 3.69.
Which companies own the most shares of Ionis Pharmaceuticals Inc (IONS)?
In terms of Ionis Pharmaceuticals Inc share price expectations, FactSet research, analysts set an average price target of 77.5 in the next 12 months, up nearly 17.78% from the previous closing price of $65.8. Analysts anticipate Ionis Pharmaceuticals Inc stock to reach 96 by 2025, with the lowest price target being 43. In spite of this, 14 analysts ranked Ionis Pharmaceuticals Inc stock as Buy at the end of 2025. On April 07, 2025, H.C. Wainwright assigned a price target of “a Buy” to the stock and initiated coverage with a $45.