Orchestra BioMed Holdings Inc [OBIO] short interest surges, jumping by 0.99 million million shares

Daniel Torres

The buying and selling of stock by a company’s insider give investors a sense that the stock will rise or fall in the future. Orchestra BioMed Holdings Inc shares valued at $20,350 were purchased by Hochman David P on Nov 14 ’25. At $4.07 per share, Hochman David P acquired 5,000 shares. The insider’s holdings grew to 612,822 shares worth approximately $2.86 million following the completion of this transaction.

Also, Aryeh Jason purchased 1,000 shares, netting a total of over 2,450 in proceeds. Following the buying of shares at $2.45 each, the insider now holds 108,482 shares.

Before that, Fain Eric S had added 5,760 shares to its account. In a trade valued at $15,034, the Director bought Orchestra BioMed Holdings Inc shares for $2.61 each. Upon closing the transaction, the insider’s holdings increased to 5,760 shares, worth approximately $0.33 million.

As published in a research note from BTIG Research on August 20, 2025, Orchestra BioMed Holdings Inc [OBIO] has been rated down from a Buy to a Neutral. Analysts at BTIG Research started covering the stock with ‘”a Buy”‘ outlook in a report released in mid March. As of January 02, 2025, Barclays has initiated its “an Overweight” rating for OBIO. Earlier on August 22, 2024, H.C. Wainwright initiated its rating. Their recommendation was “a Buy” for OBIO stock.

Analyzing OBIO Stock Performance

On last trading session, Orchestra BioMed Holdings Inc [NASDAQ: OBIO] rose 10.17% to $4.66. The stock’s lowest price that day was $4.15, but it reached a high of $4.8 in the same session. During the last five days, there has been a surge of approximately 5.43%. Over the course of the year, Orchestra BioMed Holdings Inc shares have dropped approximately -20.21%. Shares of the company reached a 52-week high of $6.30 on 01/02/25 and a 52-week low of $2.20 on 09/24/25.

Support And Resistance Levels for Orchestra BioMed Holdings Inc (OBIO)

According to the 24-hour chart, there is a support level at 4.27, which, if violated, would cause prices to drop to 3.89. In the upper region, resistance lies at 4.92. The next price resistance is at 5.19. RSI (Relative Strength Index) is 66.84 on the 14-day chart, showing neutral technical sentiment.

Is Orchestra BioMed Holdings Inc subject to short interest?

Stocks of Orchestra BioMed Holdings Inc saw a sharp rise in short interest on 2025-10-31 jumping by 0.24 million shares to 0.99 million. Data from Yahoo Finance shows that the short interest on 2025-09-30 was 0.75 million shares. A jump of 24.6% in short interest reflects a negative sentiment towards the stock. Despite the fact that short shares comprise just 2.92 of the overall float, the days-to-cover ratio (short ratio) jumped to 2.92.

Which companies own the most shares of Orchestra BioMed Holdings Inc (OBIO)?

In terms of Orchestra BioMed Holdings Inc share price expectations, FactSet research, analysts set an average price target of 12 in the next 12 months, up nearly 183.69% from the previous closing price of $4.23. Analysts anticipate Orchestra BioMed Holdings Inc stock to reach 12 by 2025, with the lowest price target being 12. On July 25, 2024, B. Riley Securities assigned a price target of “a Buy” to the stock and initiated coverage with a $15.

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