Investors can speculate about the future of a stock by watching how its insiders buy and sell stocks. Sionna Therapeutics Inc shares valued at $4,212,727 were sold by ORBIMED ADVISORS LLC on Nov 24 ’25. At $44.54 per share, ORBIMED ADVISORS LLC sold 94,583 shares. The insider’s holdings dropped to 3,610,376 shares worth approximately $158.1 million following the completion of this transaction.
Also, ORBIMED ADVISORS LLC sold 11,890 shares, netting a total of over 530,294 in proceeds. Following the sale of shares at $44.60 each, the insider now holds 3,598,486 shares.
Before that, ORBIMED ADVISORS LLC had sold 1,600 shares from its account. In a trade valued at $71,184, the Director traded Sionna Therapeutics Inc shares for $44.49 each. Upon closing the transaction, the insider’s holdings decreased to 1,600 shares, worth approximately $157.51 million.
As published in their initiating research note from BTIG Research on November 19, 2025, Sionna Therapeutics Inc [SION] has been a Buy and the price target has been revised to $50. Analysts at RBC Capital Mkts started covering the stock with ‘”a Sector perform”‘ outlook in a report released in early September. As of September 03, 2025, Raymond James has initiated its “Strong buy” rating for SION. Earlier on March 04, 2025, TD Cowen initiated its rating. Their recommendation was “a Buy” for SION stock.
Analyzing SION Stock Performance
On last trading session, Sionna Therapeutics Inc [NASDAQ: SION] plunged -1.11% to $43.79. The stock’s lowest price that day was $43.53, but it reached a high of $44.65 in the same session. During the last five days, there has been a surge of approximately 14.01%.
Support And Resistance Levels for Sionna Therapeutics Inc (SION)
According to the 24-hour chart, there is a support level at 43.28, which, if violated, would cause prices to drop to 42.77. In the upper region, resistance lies at 44.55. The next price resistance is at 45.31. RSI (Relative Strength Index) is 69.79 on the 14-day chart, showing neutral technical sentiment.
Is Sionna Therapeutics Inc subject to short interest?
Stocks of Sionna Therapeutics Inc saw a sharp steep in short interest on 2025-11-14 dropping by -0.4 million shares to 2.97 million. Data from Yahoo Finance shows that the short interest on 2025-10-15 was 3.37 million shares. A decline of -13.41% in short interest reflects a positive sentiment towards the stock. Despite the fact that short shares comprise just 10.39 of the overall float, the days-to-cover ratio (short ratio) decline to 10.39.
Which companies own the most shares of Sionna Therapeutics Inc (SION)?
In terms of Sionna Therapeutics Inc share price expectations, FactSet research, analysts set an average price target of 33.5 in the next 12 months, down nearly -24.35% from the previous closing price of $44.28. Analysts anticipate Sionna Therapeutics Inc stock to reach 45 by 2025, with the lowest price target being 22. On March 04, 2025, Stifel assigned a price target of “a Buy” to the stock and initiated coverage with a $32.
