AGIO short interest declines, indicating growing optimism among investors

Daniel Torres

Investors can expect a company’s stock to rise or fall based on the buying and selling of stock by its insiders. Agios Pharmaceuticals Inc shares valued at $8,768 were sold by Scadden David on Nov 12 ’25. At $43.84 per share, Scadden David sold 200 shares. The insider’s holdings dropped to 17,603 shares worth approximately $0.51 million following the completion of this transaction.

Also, Gheuens Sarah sold 2,454 shares, netting a total of over 107,436 in proceeds. Following the sale of shares at $43.78 each, the insider now holds 61,727 shares.

Before that, SARAH GHEUENS had added 2,454 shares to its account. In a trade valued at $107,441, the Officer bought Agios Pharmaceuticals Inc shares for $43.78 each.

As published in their initiating research note from Truist on November 24, 2025, Agios Pharmaceuticals Inc [AGIO] has been a Buy. Analysts at Leerink Partners upgraded the stock from ‘”a Market perform”‘ to ‘”an Outperform”‘ outlook in a report released in mid November. As of November 19, 2025, RBC Capital Mkts has decreased its “an Outperform” rating to a “Sector perform” for AGIO. Earlier on February 24, 2025, H.C. Wainwright initiated its rating. Their recommendation was “a Buy” for AGIO stock.

Analyzing AGIO Stock Performance

On last trading session, Agios Pharmaceuticals Inc [NASDAQ: AGIO] rose 2.16% to $29.04. The stock’s lowest price that day was $27.86, but it reached a high of $29.46 in the same session. During the last five days, there has been a surge of approximately 29.99%. Over the course of the year, Agios Pharmaceuticals Inc shares have dropped approximately -47.84%. Shares of the company reached a 52-week high of $46.00 on 11/18/25 and a 52-week low of $22.24 on 11/19/25.

Support And Resistance Levels for Agios Pharmaceuticals Inc (AGIO)

According to the 24-hour chart, there is a support level at 28.10, which, if violated, would cause prices to drop to 27.16. In the upper region, resistance lies at 29.72. The next price resistance is at 30.40. RSI (Relative Strength Index) is 36.40 on the 14-day chart, showing neutral technical sentiment.

Is Agios Pharmaceuticals Inc subject to short interest?

Stocks of Agios Pharmaceuticals Inc saw a sharp steep in short interest on 2025-11-14 dropping by -0.64 million shares to 4.33 million. Data from Yahoo Finance shows that the short interest on 2025-10-15 was 4.97 million shares. A decline of -14.82% in short interest reflects a positive sentiment towards the stock. Despite the fact that short shares comprise just 7.27 of the overall float, the days-to-cover ratio (short ratio) decline to 7.27.

Which companies own the most shares of Agios Pharmaceuticals Inc (AGIO)?

In terms of Agios Pharmaceuticals Inc share price expectations, FactSet research, analysts set an average price target of 33 in the next 12 months, up nearly 16.12% from the previous closing price of $28.42. Analysts anticipate Agios Pharmaceuticals Inc stock to reach 56 by 2025, with the lowest price target being 25. In spite of this, 5 analysts ranked Agios Pharmaceuticals Inc stock as Buy at the end of 2025.

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