Taking a Closer Look At Ionis Pharmaceuticals Inc (IONS) Following Its Recent Trade

Daniel Torres

Ionis Pharmaceuticals Inc’s recent filing unveils that its Director KLEIN JOSEPH III unloaded Company’s shares for reported $0.96 million on Nov 25 ’25. In the deal valued at $80.00 per share,12,000 shares were sold. As a result of this transaction, KLEIN JOSEPH III now holds 0 shares worth roughly $0.0.

Then, Devers Shannon L. sold 16,777 shares, generating $1,357,442 in total proceeds. Upon selling the shares at $80.91, the EVP, Chief Human Resources Ofc now owns 17,494 shares.

Before that, Devers Shannon L. bought 42,322 shares. Ionis Pharmaceuticals Inc shares valued at $3,424,273 were divested by the Officer at a price of $80.91 per share.

JP Morgan upgraded its Ionis Pharmaceuticals Inc [IONS] rating to an Overweight from a a Neutral in a research note published recently. A number of analysts have revised their coverage, including Goldman’s analysts, who increased its forecast for the stock in late September from “a Sell” to “a Neutral”. BMO Capital Markets also remained covering IONS and has increased its forecast on September 03, 2025 with a “an Outperform” recommendation from previously “Market perform” rating. Morgan Stanley revised its rating on July 31, 2025. It rated IONS as “an Overweight” which previously was an “an Equal-weight”.

Price Performance Review of IONS

On Friday, Ionis Pharmaceuticals Inc [NASDAQ:IONS] saw its stock jump 0.04% to $82.73. Over the last five days, the stock has gained 13.14%. Ionis Pharmaceuticals Inc shares have risen nearly 133.31% since the year began. Nevertheless, the stocks have risen 136.64% over the past one year. While a 52-week high of $82.90 was reached on 11/28/25, a 52-week low of $23.95 was recorded on 04/09/25.

Levels Of Support And Resistance For IONS Stock

The 24-hour chart illustrates a support level at 81.95, which if violated will result in even more drops to 81.17. On the upside, there is a resistance level at 83.23. A further resistance level may holdings at 83.73.

How much short interest is there in Ionis Pharmaceuticals Inc?

A steep rise in short interest was recorded in Ionis Pharmaceuticals Inc stocks on 2025-11-14, growing by 0.52 million shares to a total of 14.22 million shares. Yahoo Finance data shows the prior-month short interest on 2025-10-15 was 13.7 million shares. There was a rise of 3.69%, which implies that there is a positive sentiment for the stock.

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