Morgan Stanley upgrades Vertex Pharmaceuticals, Inc (VRTX) rating to an Overweight

Anna Perez

Vertex Pharmaceuticals, Inc’s filing revealed that its EVP, CO & FO WAGNER CHARLES F JR unloaded Company’s shares for reported $6.38 million on Dec 03 ’25. In the deal valued at $456.00 per share,14,000 shares were sold. As a result of this transaction, WAGNER CHARLES F JR now holds 37,725 shares worth roughly $17.05 million.

Then, Tatsis Ourania sold 4,500 shares, generating $2,024,955 in total proceeds. Upon selling the shares at $449.99, the EVP, Chief Reg. & Quality Off. now owns 46,793 shares.

Before that, LEIDEN JEFFREY M sold 63,781 shares. Vertex Pharmaceuticals, Inc shares valued at $28,650,337 were divested by the Executive Chairman at a price of $449.20 per share. As a result of the transaction, LEIDEN JEFFREY M now holds 24,026 shares, worth roughly $10.86 million.

Morgan Stanley upgraded its Vertex Pharmaceuticals, Inc [VRTX] rating to an Overweight from a an Equal-weight in a research note published recently. A number of analysts have revised their coverage, including Scotiabank’s analysts, who began to cover the stock in mid November with a ‘”a Sector outperform”‘ rating. Leerink Partners also remained covering VRTX and has increased its forecast on September 25, 2025 with a “an Outperform” recommendation from previously “Market perform” rating. Raymond James started covering the stock on September 03, 2025. It rated VRTX as “a Mkt perform”.

Price Performance Review of VRTX

On Friday, Vertex Pharmaceuticals, Inc [NASDAQ:VRTX] saw its stock jump 1.37% to $452.04. Over the last five days, the stock has lost -0.76%. Vertex Pharmaceuticals, Inc shares have fallen nearly -3.66% since the year began. Nevertheless, the stocks have risen 12.25% over the past one year. While a 52-week high of $519.68 was reached on 03/14/25, a 52-week low of $362.50 was recorded on 08/11/25.

Levels Of Support And Resistance For VRTX Stock

The 24-hour chart illustrates a support level at 445.90, which if violated will result in even more drops to 439.76. On the upside, there is a resistance level at 457.09. A further resistance level may holdings at 462.14.

How much short interest is there in Vertex Pharmaceuticals, Inc?

A steep rise in short interest was recorded in Vertex Pharmaceuticals, Inc stocks on 2025-11-28, growing by 0.32 million shares to a total of 4.46 million shares. Yahoo Finance data shows the prior-month short interest on 2025-10-31 was 4.13 million shares. There was a rise of 7.26%, which implies that there is a positive sentiment for the stock.

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