SION’s short interest shows a sharp rise on 2025-09-15

The buying and selling of stock by a company’s insider give investors a sense that the stock will rise or fall in the future. Sionna Therapeutics Inc shares valued at $1,132,380 were sold by Booth Bruce on Oct 03 ’25. At $30.00 per share, Booth Bruce sold 37,746 shares. The insider’s holdings dropped to 787,527 shares worth approximately $22.33 million following the completion of this transaction.

Also, Booth Bruce sold 11,800 shares, netting a total of over 353,410 in proceeds. Following the sale of shares at $29.95 each, the insider now holds 785,480 shares.

Before that, Atlas Venture Opportunity Fund had added 2,047 shares to its account. In a trade valued at $61,430, the Shareholder bought Sionna Therapeutics Inc shares for $30.01 each.

As published in their initiating research note from RBC Capital Mkts on September 03, 2025, Sionna Therapeutics Inc [SION] has been a Sector perform and the price target has been revised to $22. Analysts at Raymond James started covering the stock with ‘”a Strong buy”‘ outlook in a report released in early September. As of March 04, 2025, TD Cowen has initiated its “Buy” rating for SION. Earlier on March 04, 2025, Stifel initiated its rating. Their recommendation was “a Buy” for SION stock.

Analyzing SION Stock Performance

On last trading session, Sionna Therapeutics Inc [NASDAQ: SION] plunged -0.53% to $28.35. The stock’s lowest price that day was $24.88, but it reached a high of $28.51 in the same session. During the last five days, there has been a drop of approximately -3.24%.

Support And Resistance Levels for Sionna Therapeutics Inc (SION)

According to the 24-hour chart, there is a support level at 25.83, which, if violated, would cause prices to drop to 23.31. In the upper region, resistance lies at 29.69. The next price resistance is at 31.03. RSI (Relative Strength Index) is 59.71 on the 14-day chart, showing neutral technical sentiment.

Is Sionna Therapeutics Inc subject to short interest?

Stocks of Sionna Therapeutics Inc saw a sharp rise in short interest on 2025-09-15 jumping by 0.17 million shares to 3.77 million. Data from Yahoo Finance shows that the short interest on 2025-08-15 was 3.6 million shares. A jump of 4.55% in short interest reflects a negative sentiment towards the stock. Despite the fact that short shares comprise just 14.82 of the overall float, the days-to-cover ratio (short ratio) jumped to 14.82.

Which companies own the most shares of Sionna Therapeutics Inc (SION)?

In terms of Sionna Therapeutics Inc share price expectations, FactSet research, analysts set an average price target of 33.5 in the next 12 months, up nearly 17.54% from the previous closing price of $28.5. Analysts anticipate Sionna Therapeutics Inc stock to reach 45 by 2025, with the lowest price target being 22. On March 04, 2025, Guggenheim assigned a price target of “a Buy” to the stock and initiated coverage with a $45.

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