A Guide To The Risks Of Investing In Orchestra BioMed Holdings Inc (OBIO)

Anna Perez

Orchestra BioMed Holdings Inc’s filing revealed that its insider Hochman David P acquired Company’s shares for reported $20350.0 on Nov 14 ’25. In the deal valued at $4.07 per share,5,000 shares were bought. As a result of this transaction, Hochman David P now holds 612,822 shares worth roughly $2.67 million.

Then, Aryeh Jason bought 1,000 shares, generating $2,450 in total proceeds. Upon buying the shares at $2.45, the Director now owns 108,482 shares.

Before that, Fain Eric S bought 5,760 shares. Orchestra BioMed Holdings Inc shares valued at $15,034 were divested by the Director at a price of $2.61 per share. As a result of the transaction, Fain Eric S now holds 71,709 shares, worth roughly $0.31 million.

TD Cowen initiated its Orchestra BioMed Holdings Inc [OBIO] rating to a Buy in a research note published on December 10, 2025; the price target was $15. A number of analysts have revised their coverage, including BTIG Research’s analysts, who decreased its forecast for the stock in mid August from “a Buy” to “a Neutral”. BTIG Research began covering OBIO with “Buy” recommendation on March 20, 2025. Barclays started covering the stock on January 02, 2025. It rated OBIO as “an Overweight”.

Price Performance Review of OBIO

On Friday, Orchestra BioMed Holdings Inc [NASDAQ:OBIO] saw its stock jump 0.23% to $4.35. Over the last five days, the stock has lost -3.55%. Orchestra BioMed Holdings Inc shares have fallen nearly -11.94% since the year began. Nevertheless, the stocks have risen 8.75% over the past one year. While a 52-week high of $6.30 was reached on 01/02/25, a 52-week low of $2.20 was recorded on 09/24/25.

Levels Of Support And Resistance For OBIO Stock

The 24-hour chart illustrates a support level at 4.13, which if violated will result in even more drops to 3.91. On the upside, there is a resistance level at 4.51. A further resistance level may holdings at 4.66.

How much short interest is there in Orchestra BioMed Holdings Inc?

A steep rise in short interest was recorded in Orchestra BioMed Holdings Inc stocks on 2025-11-28, dropping by -0.22 million shares to a total of 0.77 million shares. Yahoo Finance data shows the prior-month short interest on 2025-10-31 was 0.99 million shares. There was a decline of -27.82%, which implies that there is a negative sentiment for the stock.

The most recent change occurred on August 22, 2024 when H.C. Wainwright began covering the stock and recommended ‘”a Buy”‘ rating along with a $14 price target.

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