Investors can speculate about the future of a stock by watching how its insiders buy and sell stocks. Sionna Therapeutics Inc shares valued at $40,050 were sold by ORBIMED ADVISORS LLC on Dec 17 ’25. At $44.50 per share, ORBIMED ADVISORS LLC sold 900 shares. The insider’s holdings dropped to 3,595,986 shares worth approximately $158.33 million following the completion of this transaction.
Also, ORBIMED ADVISORS LLC sold 875 shares, netting a total of over 38,929 in proceeds. Following the sale of shares at $44.49 each, the insider now holds 3,595,011 shares.
Before that, ORBIMED ADVISORS LLC had sold 100 shares from its account. In a trade valued at $4,449, the Director traded Sionna Therapeutics Inc shares for $44.49 each. Upon closing the transaction, the insider’s holdings decreased to 100 shares, worth approximately $158.33 million.
As published in a research note from RBC Capital Mkts on December 01, 2025, Sionna Therapeutics Inc [SION] has been rated down from a Sector perform to an Underperform and the price target has been revised to $24. Analysts at BTIG Research started covering the stock with ‘”a Buy”‘ outlook in a report released in mid November. As of September 03, 2025, RBC Capital Mkts has initiated its “Sector perform” rating for SION. Earlier on September 03, 2025, Raymond James initiated its rating. Their recommendation was “a Strong buy” for SION stock.
Analyzing SION Stock Performance
On last trading session, Sionna Therapeutics Inc [NASDAQ: SION] rose 1.35% to $44.03. The stock’s lowest price that day was $43.815, but it reached a high of $44.7 in the same session. During the last five days, there has been a surge of approximately 2.17%.
Support And Resistance Levels for Sionna Therapeutics Inc (SION)
According to the 24-hour chart, there is a support level at 43.66, which, if violated, would cause prices to drop to 43.29. In the upper region, resistance lies at 44.55. The next price resistance is at 45.07. RSI (Relative Strength Index) is 62.28 on the 14-day chart, showing neutral technical sentiment.
Is Sionna Therapeutics Inc subject to short interest?
Stocks of Sionna Therapeutics Inc saw a sharp steep in short interest on 2025-11-28 dropping by -0.1 million shares to 2.86 million. Data from Yahoo Finance shows that the short interest on 2025-10-31 was 2.97 million shares. A decline of -3.61% in short interest reflects a positive sentiment towards the stock. Despite the fact that short shares comprise just 12.97 of the overall float, the days-to-cover ratio (short ratio) decline to 12.97.
Which companies own the most shares of Sionna Therapeutics Inc (SION)?
In terms of Sionna Therapeutics Inc share price expectations, FactSet research, analysts set an average price target of 34.5 in the next 12 months, down nearly -20.58% from the previous closing price of $43.44. Analysts anticipate Sionna Therapeutics Inc stock to reach 45 by 2025, with the lowest price target being 24.
