Short interest on AGIO sees a significant increase on 2025-10-15

Roman Campbell

Investors can speculate about the future of a stock by watching how its insiders buy and sell stocks. Agios Pharmaceuticals Inc shares valued at $8,762 were sold by Gheuens Sarah on Oct 30 ’25. At $43.81 per share, Gheuens Sarah sold 200 shares. The insider’s holdings dropped to 61,727 shares worth approximately $2.5 million following the completion of this transaction.

Also, SARAH GHEUENS purchased 200 shares, netting a total of over 8,762 in proceeds.

Before that, Gheuens Sarah had sold 3,302 shares from its account. In a trade valued at $145,024, the Chief Medical Officer traded Agios Pharmaceuticals Inc shares for $43.92 each. Upon closing the transaction, the insider’s holdings decreased to 3,302 shares, worth approximately $2.5 million.

As published in their initiating research note from H.C. Wainwright on February 24, 2025, Agios Pharmaceuticals Inc [AGIO] has been a Buy and the price target has been revised to $58. Analysts at Scotiabank started covering the stock with ‘”a Sector outperform”‘ outlook in a report released in mid October. Earlier on September 27, 2024, Leerink Partners downgraded its rating. Their new recommendation was “a Market perform” for AGIO stock which previously was a “an Outperform”.

Analyzing AGIO Stock Performance

On last trading session, Agios Pharmaceuticals Inc [NASDAQ: AGIO] rose 1.27% to $40.51. The stock’s lowest price that day was $39.21, but it reached a high of $40.72 in the same session. During the last five days, there has been a drop of approximately -3.46%. Over the course of the year, Agios Pharmaceuticals Inc shares have dropped approximately -9.72%. Shares of the company reached a 52-week high of $44.25 on 10/27/25 and a 52-week low of $23.42 on 04/09/25.

Support And Resistance Levels for Agios Pharmaceuticals Inc (AGIO)

According to the 24-hour chart, there is a support level at 39.57, which, if violated, would cause prices to drop to 38.64. In the upper region, resistance lies at 41.08. The next price resistance is at 41.66. RSI (Relative Strength Index) is 46.89 on the 14-day chart, showing neutral technical sentiment.

Is Agios Pharmaceuticals Inc subject to short interest?

Stocks of Agios Pharmaceuticals Inc saw a sharp rise in short interest on 2025-10-15 jumping by 0.24 million shares to 4.97 million. Data from Yahoo Finance shows that the short interest on 2025-09-15 was 4.74 million shares. A jump of 4.78% in short interest reflects a negative sentiment towards the stock. Despite the fact that short shares comprise just 8.71 of the overall float, the days-to-cover ratio (short ratio) jumped to 8.71.

Which companies own the most shares of Agios Pharmaceuticals Inc (AGIO)?

In terms of Agios Pharmaceuticals Inc share price expectations, FactSet research, analysts set an average price target of 56 in the next 12 months, up nearly 40.0% from the previous closing price of $40.0. Analysts anticipate Agios Pharmaceuticals Inc stock to reach 56 by 2025, with the lowest price target being 56. In spite of this, 5 analysts ranked Agios Pharmaceuticals Inc stock as Buy at the end of 2025.

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